Keywords
global burden
infections
resistance
sub-Sahara
How to Cite
Abstract
Infectious diseases continue to be a major global problem in public health, accounting for millions of fatalities annually, despite a century of frequently successful preventative and control efforts. Antimicrobial resistance (AMR) and the appearance of novel diseases are both consequences of the rapid pace at which society, technology, and microbes are changing. It is projected that AMR was responsible for the deaths of 700,000 people around the world in 2014, making it one of the most significant threats to the world's public health. This essay points to the challenges of antimicrobial resistance in sub-Saharan Africa and its prospects. An online search was done on relevant published studies in PubMed, Scopus, Embase, and ResearchGate from the period 1992 to 2023, of which 61 were adapted for this article. The sub-Saharan Africa region, despite being the worst hit when it comes to infectious disease and, by proxy, antimicrobial resistance, can win the war in the long run.
References
Aarestrup, F. M. (1999). Association between the consumption of antimicrobial agents in animal husbandry and the occurrence of resistant bacteria among food animals. International Journal of Antimicrobial Agents, 12(4), 279-285.
Aarestrup, F.M. (2005). The origin, evolution, and local and global dissemination of antimicrobial resistance. In: Antimicrobial resistance in bacteria of animal origin, Chapter 20, pp. 339-359.
Abushaheen, M. A., Fatani, A. J., Alosaimi, M., Mansy, W., George, M., Acharya, S., Rathod, S., Divakar, D. D., Jhugroo, C., Vellappally, S., & Khan, A. A. (2020). Antimicrobial resistance, mechanisms, and its clinical significance. Disease-a-Month, 66(6), 100971.
Acar, J., & Rostel, B. (2001). Antimicrobial resistance: an overview. Revue Scientifique et Technique-Office International des Epizooties, 20(3), 797-810.
Alghamdi, S. (2021). The role of vaccines in combating antimicrobial resistance (AMR) bacteria. Saudi Journal of Biological Sciences, 28(12), 7505-7510.
Annunziato, G. (2019). Strategies to Overcome Antimicrobial Resistance (AMR) Making Use of Non-Essential Target Inhibitors: A Review. International Journal of Molecular Sciences, 20(23), 5844.
Antimicrobial Resistance Collaborators (2022). Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet, 399(10325), 629-655. Erratum in: Lancet, 400(10358), 1102.
Aslam, B., Wang, W., Arshad, M. I., Khurshid, M., Muzammil, S., Rasool, M. H., Nisar, M. A., Alvi, R. F., Aslam, M. A., Qamar, M. U., Salamat, M. K. F., & Baloch, Z. (2018). Antibiotic resistance: a rundown of a global crisis. Infection and Drug Resistance, 11, 1645-1658.
Atanasov, A. G., Zotchev, S. B., & Dirsch, V. M., the International Natural Product Sciences Taskforce, Supuran, C. T. (2012). Natural products in drug discovery: advances and opportunities. National Review of Drug Discovery, 20, 200–216
Ayon, N. J. (2023). High-Throughput Screening of Natural Product and Synthetic Molecule Libraries for Antibacterial Drug Discovery. Metabolites, 13(5), 625.
Babatola, A. O., Fadare, J. O., Olatunya, O. S., Obiako, R., Enwere, O., Kalungia, A., Ojo, T. O., Sunmonu, T. A., Desalu, O., & Godman, B. (2021). Addressing antimicrobial resistance in Nigerian hospitals: exploring physicians prescribing behavior, knowledge, and perception of antimicrobial resistance and stewardship programs. Expert Review of Anti-Infective Therapy, 19(4), 537-546.
Baker, R. E., Mahmud, A. S., Miller, I. F., Rajeev, M., Rasambainarivo, F., Rice, B. L., Takahashi, S., Tatem, A. J., Wagner, C. E., Wang, L. F., Wesolowski, A., & Metcalf, C. J. E. (2022). Infectious disease in an era of global change. Natural Review of Microbiology, 20(4),193-205.
Balsalobre, L. C., Dropa, M., & Matté, M. H. (2014). An overview of antimicrobial resistance and its public health significance. Brazillian Journal of Microbiology, 45, 1-6.
Belachew, S. A., Hall, L., & Selvey, L. A. (2021). Non-prescription dispensing of antibiotic agents among community drug retail outlets in Sub-Saharan African countries: a systematic review and meta-analysis. Antimicrobial Resistance and Infection Control, 10, 13.
Bloom, D. E., & Cadarette, D. (2019). Infectious Disease Threats in the Twenty-First Century: Strengthening the Global Response. Frontiers in Immunology, 10, 549.
Bonfiglio, G., Neroni, B., Radocchia, G., Marazzato, M., Pantanella, F., & Schippa, S. (2020). Insight into the Possible Use of the Predator Bdellovibrio bacteriovorus as a Probiotic. Nutrients, 12(8), 2252.
Bratanis, E., Andersson, T., Lood, R., & Bukowska-Faniband, E. (2020). Biotechnological Potential of Bdellovibrio and Like Organisms and Their Secreted Enzymes. Frontiers in Microbiology, 11, 662.
Chukwu, E. E., Oladele, D. A., Awoderu, O. B., Afocha, E. E., Lawal, R. G., Abdus-Salam, I., Ogunsola, F. T., & Audu, R. A. (2020). A national survey of public awareness of antimicrobial resistance in Nigeria. Antimicrobial Resistance and Infection Control, 9(1), 1-10.
Cohen, M. L. (2000). Changing patterns of infectious disease. Nature, 406(6797), 762-767.
Dagan, R., & Klugman, K. P. (2008). Impact of conjugate pneumococcal vaccines on antibiotic resistance. The The The The The Lancet Infectious Diseases, 8(12), 785-795.
Del Pozo, J. L., & Patel, R. (2007). The challenge of treating biofilm‐associated bacterial infections. Clinical Pharmacology and Therapeutics, 82(2), 204-209.
Dzobo, K. (2022). The Role of Natural Products as Sources of Therapeutic Agents for Innovative Drug Discovery. Comprehensive Pharmacology, 408–22.
Elton, L., Thomason, M. J., Tembo, J., Velavan, T. P., Pallerla, S. R., Arruda, L. B., Vairo, F., Montaldo, C., Ntoumi, F., Abdel-Hamid, M. M., & Haider, N. (2020). Antimicrobial resistance preparedness in sub-Saharan African countries. Antimicrobial Resistance and Infection Control, 9, 1-11.
Fabijan, P. A., Iredell, J., Danis-Wlodarczyk, K., Kebriaei, R., & Abedon, S. T. (2023). Translating phage therapy into the clinic: Recent accomplishments but continuing challenges. PLoS Biology, 21(5), e3002119.
Fukuoka, T., Ohya, S., Narita, T., Katsuta, M., Iijima, M., Masuda, N., Yasuda, H., Trias, J., & Nikaido, H. (1993). Activity of the carbapenem panipenem and role of the OprD (D2) protein in its diffusion through the Pseudomonas aeruginosa outer membrane. Antimicrobial Agents and Chemotherapy, 37(2), 322-327.
Giedraitienė, A., Vitkauskienė, A., Naginienė, R., & Pavilonis, A. (2011). Antibiotic resistance mechanisms of clinically important bacteria. Medicina, 47(3), 19.
Godman, B., Egwuenu, A., Wesangula, E., Schellack, N., Kalungia, A. C., Tiroyakgosi, C., Kgatlwane, J., Mwita, J. C., Patrick, O., Niba, L. L., & Amu, A. A. (2022). Tackling antimicrobial resistance across sub-Saharan Africa: Current challenges and implications for the future. Expert Opinion on Drug Safety 21(8), 1089-1111.
Gulumbe, B. H., Haruna, U. A., Almazan, J., Ibrahim, I. H., Faggo, A. A., & Bazata, A. Y. (2022). Combating the menace of antimicrobial resistance in Africa: a review on stewardship, surveillance, and diagnostic strategies. Biological Proceedings Online, 24(1), 19.
Høiby, N., Bjarnsholt, T., Givskov, M., Molin, S., & Ciofu, O. (2010). Antibiotic resistance of bacterial biofilms. International Journal of Antimicrobial Agents, 35(4), 322-332.
Kariuki, S., & Dougan, G. (2014). Antibacterial resistance in sub‐Saharan Africa: an underestimated emergency. Annals of New York Academy of Sciences, 1323(1), 43-55.
Kariuki, S., Kering, K., Wairimu, C., Onsare, R., & Mbae, C. (2022) Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now? Infection and Drug Resistance, 3589-3609.
Klein, E. Y., Van Boeckel, T. P., Martinez, E. M., Pant, S., Gandra, S., Levin, S. A., et al. (2018). Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc of the National Academy of Science USA, 115(15), E3463–70.
Kourkouta, L., Koukourikos, K., Iliadis, C., Plati, P., & Dimitriadou, A. (2018). History of antibiotics. Sumerian Journal of Medine and Healthcare, 1, 51-55.
Laverty, G., Gorman, S. P., & Gilmore, B. F. (2014). Biomolecular mechanisms of Pseudomonas aeruginosa and Escherichia coli biofilm formation. Pathogens, 3(3), 596-632.
Leung, E., Weil, D. E., Raviglione, M., & Nakatani, H. (2011). The WHO policy package to combat antimicrobial resistance. Bulletin of the World Health Organisation, 89, 390-392.
Ling, L.L., Schneider, T., Peoples, A.J., Spoering, A.L., Engels, I., Conlon, B.P., Mueller, A., Schäberle, T.F., Hughes, D.E., Epstein, S., & Jones, M. (2015). A new antibiotic kills pathogens without detectable resistance. Nature, 517(7535), 455-459.
Marston, H.D., Dixon, D.M., Knisely, J.M., Palmore, T.N., & Fauci, A.S. (2016). Antimicrobial resistance. JAMA, 316(11), 1193-1204.
Micoli, F., Bagnoli, F., Rappuoli, R., & Serruto, D. (2021). The role of vaccines in combatting antimicrobial resistance. Nature Reviews Microbiology, 19, 287–302
Moke, E.G., Umukoro, E.K., Edje, K.E., & Udele, D. (2019). Practice of Self-Medication with Antibiotics Among Basic Medical Science Students of a Nigerian Tertiary Institution. International Journal of Advanced Research, 7(11), 915-919.
Murugaiyan, J., Kumar, P. A., Rao, G. S., Iskandar, K., Hawser, S., Hays, J. P., Mohsen, Y., Adukkadukkam, S., Awuah, W. A., Jose, R. A. M., Sylvia, N., Nansubuga, E. P., Tilocca, B., Roncada, P., Roson-Calero, N., Moreno-Morales, J., Amin, R., Kumar, B. K., Kumar, A., Toufik, A. R., Zaw, T. N., Akinwotu, O. O., Satyaseela, M. P., & van Dongen, M. B. M. (2022). Progress in Alternative Strategies to Combat Antimicrobial Resistance: Focus on Antibiotics. Antibiotics (Basel), 11(2), 200.
Ndihokubwayo, J.B., Yahaya, A.A., Desta, A.T., Ki-Zerbo, G., Odei, E.A., Keita, B., Pana, A.P., & Nkhoma, W. (2013). Antimicrobial resistance in the African Region: Issues, challenges and actions proposed. African Health Monitor, 16, 27-30.
Nikaido, H. (1992). Porins and specific channels of bacterial outer membranes. Molecular Microbiology, 6(4), 435-442.
Nikaido, H., & Pagès, J. M. (2012). Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteria. FEMS Microbiology Review, 36(2), 340-363.
Nwobodo, D. C., Ugwu, M. C., Anie, C. O., Al-Ouqaili, M. T. S., Ikem, J. C., Chigozie, U. V., & Saki, M. (2022). Antibiotic resistance: The challenges and some emerging strategies for tackling a global menace. Journal of Clinical Laboratory Analysis, 36(9), e24655.
Omo-Aghoja, L., Moke, E. G., Anachuna, K. K., Omogbiya, A. I., Umukoro, E. K., Toloyai, P. Y., Daubry, T. M. E., & Eduviere, A. T. (2021). COVID-19 pandemic: the implications of the natural history, challenges of diagnosis and management for care in sub-Saharan Africa. Beni-Suef University Journal of Basic Applied Sciences, 10(1), 1-16.
Peltola, H. (2000). Worldwide Haemophilus influenzae type b disease at the beginning of the 21st century: global analysis of the disease burden 25 years after the use of the polysaccharide vaccine and a decade after the advent of conjugates. Clinical Microbiology Review, 13(2), 302-317.
Pucci, M. J., & Dougherty, T. J. (2002). Direct quantitation of the numbers of individual penicillin-binding proteins per cell in Staphylococcus aureus. Journal of Bacteriology, 184(2), 588-591.
Santajit, S., & Indrawattana, N. (2016). Mechanisms of antimicrobial resistance in ESKAPE pathogens. Biomedical Research Intitute.
Schweizer, H. P. (2003). Efflux as a mechanism of resistance to antimicrobials in Pseudomonas aeruginosa and related bacteria: unanswered questions. Genetic and Molecular Research, 2(1), 48-62.
Sekyere, J.O., & Asante, J. (2018). Emerging mechanisms of antimicrobial resistance in bacteria and fungi: advances in the era of genomics. Future Microbiology, 13(2), 241-262.
Sengupta, S., Chattopadhyay, M. K., & Grossart, H. P. (2013). The multifaceted roles of antibiotics and antibiotic resistance in nature. Frontiers in Microbiology, 4, 47.
Sharma, G., Rao, S., Bansal, A., Dang, S., Gupta, S., & Gabrani, R. (2014). Pseudomonas aeruginosa biofilm: potential therapeutic targets. Biologicals, 42(1), 1-7.
Shree, S., Suman, E., Kotian, H., Paul, S. H., & M. S. S. (2023). Effect of Klebsiella-specific phage on multidrug-resistant Klebsiella pneumoniae- an experimental study. Indian Journal of Medical Microbiology, 47, 100515.
Silbergeld, E.K., Davis, M., Leibler, J.H., & Peterson, A.E. (2008). One reservoir: redefining the community origins of antimicrobial-resistant infections. Medical Clinics North America, 92(6), 1391-1407.
Sun, J., Deng, Z., & Yan, A. (2014). Bacterial multidrug efflux pumps: mechanisms, physiology and pharmacological exploitations. Biomedical and Biophysical Research Communications, 453(2), 254-267.
Vaez, H., Faghri, J., Isfahani, B. N., Moghim, S., Yadegari, S., Fazeli, H., Moghofeei, M., & Safaei, H. G. (2014). Efflux pump regulatory genes mutations in multidrug resistance Pseudomonas aeruginosa isolated from wound infections in Isfahan hospitals. Advanced Biomedical Research, 3.
Williams, P. C., Isaacs, D., & Berkley, J. A. (2018). Antimicrobial resistance among children in sub-Saharan Africa. The Lancet Infectious Diseases, 18(2), e33-e44.
World Health Organization (WHO) (2011). Establishment of national laboratory-based surveillance of antibiotic resistance (No. SEA-HLM-415). WHO Regional Office for South-East Asia.
Young, F., Critchley, J. A., Johnstone, L. K., & Unwin, N. C. (2009). A review of co-morbidity between infectious and chronic disease in Sub Saharan Africa: TB and diabetes mellitus, HIV and metabolic syndrome, and the impact of globalization. Global Health, 5, 1-9.
Zaffiri, L., Gardner, J., & Toledo-Pereyra, L.H. (2012). History of antibiotics. From salvarsan to cephalosporins. Journal of Investigative Surgery, 25(2), 67-77.
Zhang, X. X., Jin, Y. Z., Lu, Y. H., Huang, L. L., Wu, C. X., Lv, S., Chen, Z., Xiang, H., & Zhou, X. N. (2023). Infectious disease control: from health security strengthening to health systems improvement at global level. Global Health Research Policy, 8, 38.
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