https://orapuh.org/ojs/ojs-3.1.2-4/index.php/orapj/issue/feedOrapuh Journal2024-03-21T23:07:14+00:00Prof. V. E. Adamu[email protected]Open Journal Systems<p>Orapuh Journal <em>(Orap J) - ISSN: <strong>2644-3740</strong></em> is an Open Access, internationally peer-reviewed online Journal of Oral and Public Health. The Journal exists to deliver simple, quality, and best-in-class, peer-reviewed oral and public health knowledge to oral and public health care professionals, educators, consumers, and the global community.</p> <p><strong>Aim</strong></p> <p>Orapuh Journal aims to catalyze aggravated access to superior information and research and encourage the development of new researchers/authors from the underserved biases of the oral and public health disciplines.</p> <p><strong>Scope</strong></p> <p>Orap J prioritises original research, balanced, comprehensive, or critical review articles, good, evidence-based information, and interactive clinical and related content from the oral and public health disciplines.</p> <p><strong>Open Access Information</strong></p> <p>All articles in Orap J are open-access articles distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License.</p> <p>Click <a href="https://www.orapuh.org/ojs/ojs-3.1.2-4/index.php/orapj/about"><strong>here</strong></a> to read more about the Journal. Find out <a href="http://orapuh.org/ojs/ojs-3.1.2-4/index.php/orapj/why-choose">why <em>Orap J</em> is your quick access to being</a>!</p> <p><strong><a href="https://orapuh.org/2023/11/01/the-vital-role-of-communicating-dental-and-public-health-research-findings/">Click here</a></strong> to read an article about the vital role of communicating oral and public health research findings to the scientific community.</p> <p><a href="http://orapuh.org/ojs/ojs-3.1.2-4/index.php/orapj/editorial-policies">Editorial Policies</a> <a href="https://orapuh.org/ojs/ojs-3.1.2-4/index.php/orapj/about/editorialTeam">Editorial Team</a> <a href="http://orapuh.org/ojs/ojs-3.1.2-4/index.php/orapj/about/submissions">Author Guidelines</a></p>https://orapuh.org/ojs/ojs-3.1.2-4/index.php/orapj/article/view/e1111Molecular Docking Simulation of the antisickling activity of Naringenin-7-O-glucoside and Kaempferol-3-O-glucoside from Uapaca heudelotii Baill. (Phyllanthaceae) and their ADMET profile 2024-03-21T23:07:13+00:00Grégoire Elumba Ekutsu[email protected]Emmanuel Mulongo Kitete[email protected]Colette Ashande Masengo[email protected]Benjamin Z. Gbolo[email protected]Jeff Bekomo Iteku[email protected]Bienvenu K. Mavakala[email protected]Pius Tshimankinda Mpiana[email protected]Virima Mudogo[email protected]Jean-Paul Koto-Te-Nyiwa Ngbolua[email protected]<p><strong>Introduction</strong><br>Sickle cell disease is a genetic disease that affects the hemoglobin in red blood cells. The symptoms of this public health problem include anemia, painful crises, and an increased risk of infections. In the Democratic Republic of the Congo, the medicinal plant species Uappaca heudelotii, which has been reported to have antisickling activity in vitro constitutes a source of natural antisickling agents for potential clinical applications in sickle cell disease management. <br><strong>Purpose</strong><br>This study aimed to investigate the potential of two secondary metabolites (Naringenin-7-O-glucoside and Kaempferol-3-O-glucoside) from Uappaca heudelotii in treating sickle cell disease by targeting specific receptors (3NFY, 3WCU, 5VTB, and 7EJ1) associated with the condition.<br><strong>Methods</strong><br>Naringenin-7-O-glucoside and Kaempferol-3-O-glucoside from U. heudelotii were evaluated for their interaction with receptors associated with sickle cell disease namely 3NFY, 3WCU, 5VTB, and 7EJ1 using molecular docking simulation. Discovery Studio 2021 (Biovia) software package was used to prepare the receptor, to edit the binding site, and to visualize the results of docking. SWISS ADME and PKCSM bioinformatics tools were utilized for assessing physicochemical parameters and pharmacokinetic properties, respectively.<br><strong>Results</strong><br>Naringenin-7-O-glucoside and Kaempferol-3-O-glucoside exhibited significant interactions with the receptors; Both compounds formed hydrogen bonds with the receptors, indicating strong binding affinity; Naringenin-7-O-glucoside formed 4, 1, 6, and 3 hydrogen bonds with receptors 3NFY, 3WCU, 5VTB, and 7EJ1 respectively; Kaempferol-3-O-glucoside formed 5, 5, 8, and 2 hydrogen bonds with the same receptors respectively, indicating a higher number of interactions.<br><strong>Conclusions</strong> <br>The study confirmed the potential of Naringenin-7-O-glucoside and Kaempferol-3-O-glucoside from U. heudelotii as effective agents against sickle cell disease. These compounds demonstrate promising antisickling properties by inhibiting hemoglobin polymerization and the Rapoport-Lübering shunt, rehydrating erythrocytes, and increasing fetal hemoglobin levels.</p>2024-03-20T22:32:05+00:00Copyright (c) 2024 Grégoire Elumba Ekutsu, Emmanuel Mulongo Kitete, Colette Ashande Masengo, Benjamin Z. Gbolo, Jeff Bekomo Iteku, Bienvenu K. Mavakala, Pius Tshimankinda Mpiana, Virima Mudogo, Jean-Paul Koto-Te-Nyiwa Ngboluahttps://orapuh.org/ojs/ojs-3.1.2-4/index.php/orapj/article/view/e1112X-ray fluorescence characterization of some medicinal plants traditionally used as aphrodisiac in the treatment of male sterility in Kenge City, Democratic Republic of the Congo2024-03-21T23:07:13+00:00Frederick Ndombe Mulwele[email protected]Koto-Te-Nyiwa Ngbolua[email protected]B Yang Da Musa Masens[email protected]Théophile Fundu Mbemba[email protected]Pius Tshimankinda Mpiana[email protected]<p><strong>Introduction</strong><br>Male infertility refers to the inability of a man to impregnate a woman. It is a public health issue among men of reproductive age. Certain minerals, such as zinc, selenium, iron, and magnesium, are essential to produce healthy sperm and for maintaining male reproductive function. Medicinal plants containing these minerals can improve sperm quality and increase the chances of conception in men suffering from infertility.<br><strong>Purpose</strong><br>The aim of this research was to analyze the elemental composition of four medicinal plants traditionally used for their aphrodisiac properties, with a particular emphasis on their application in the treatment of male sterility. <br>Methods<br>The mineral content of selected plants was assessed by X-ray fluorescence using Energy Dispersive XRF Spectrometer (EDXRF).<br><strong>Results</strong><br>The findings reveal significant concentrations of various minerals in the studied medicinal plants, providing crucial information about their elemental composition. Thirty mineral elements were identified, including six macro elements (Na, Mg, P, S, K, Ca), 15 micro elements (Al, Si, Mn, Ni, Cu, Mo, Pb, Ti, V, Cr, Hg, Br, Rb, Sr, and Cd), three important elements in the diet of spermatozoa (Fe, Zn, Mg), and seven non-relevant elements. These results can have direct implications for the medicinal properties of the plants, especially in the context of treating male sterility.<br><strong>Conclusions</strong><br>Among the selected medicinal plants, Mondia whitei is rich in minerals as evidenced by principal component analysis (PCA) and could potentially contribute to improving overall health and indirectly promoting male fertility. the</p>2024-03-20T22:04:04+00:00Copyright (c) 2024 Frederick Ndombe Mulwele, Koto-Te-Nyiwa Ngbolua, B Yang Da Musa Masens, Théophile Fundu Mbemba, Pius Tshimankinda Mpianahttps://orapuh.org/ojs/ojs-3.1.2-4/index.php/orapj/article/view/e1113The Factors associated with the practice of self-medication in Barumbu Health Zone, Democratic Republic of the Congo2024-03-21T23:07:12+00:00Augustin KADIATA BUKASA[email protected]Augustin Tshitadi Makangu[email protected]Pascal Atuba Mamenepi[email protected]Marcel Tshidibi Bukasa[email protected]Sébastien Kazumba Mamba[email protected]Félicien Tshimungu Kandolo[email protected]<p><strong>Introduction</strong> <br>The issue of resorting to self-medication is currently common and no geographical area is spared from it in the world. Millions of people prefer to treat minor ailments rather than follow formal treatment.<br><strong>Purpose</strong><br>This study aimed to determine the factors associated with self-medication in the Barumbu Health Zone.<br><strong>Methods</strong><br>This is a descriptive correlational and cross-sectional study carried out in the city of Kinshasa, and more precisely in the Barumbu Health Zone. The sample was 266 heads of households. The questionnaire survey method was used with the structured interview technique to collect the data.<br><strong>Results</strong><br>After analysis with SPSS version 20 software, we arrived at the results according to which self-medication is practiced by 76.6%. Level of education (secondary) (X2 8.084, p=0.044) and monthly income ≤ 100$ (2 20.445., p=0.000) are associated with the practice of self-medication. Insufficient knowledge about the consequences of self-medication (X2 8.872, p= 0. 003), insufficient membership of mutual health insurance companies (X2 16,677, p=0.000), and the high cost of care (X2 30,304, p=0.000), are factors associated with the practice of self-medication in the commune of Barumbu, Kinshasa.<br><strong>Conclusion</strong><br>The revision of health care fees in all health care structures to allow everyone to access health care, the mobilisation to join mutual health insurance companies, and the sensitisation to the consequences of self-medication will allow to reduce this practice significantly.</p>2024-03-20T23:51:18+00:00Copyright (c) 2024 Augustin KADIATA BUKASA, Augustin Tshitadi Makangu, Pascal Atuba Mamenepi, Marcel Tshidibi Bukasa, Sébastien Kazumba Mamba, Félicien Tshimungu Kandolohttps://orapuh.org/ojs/ojs-3.1.2-4/index.php/orapj/article/view/244Enhancing oral and public health scholarship at Orapuh: Unveiling the Orapuh vocabulary2024-03-21T23:07:14+00:00V. E. Adamu[email protected]Ndidiamaka Ijeoma Eneojo[email protected]<p>The Orapuh Vocabulary represents a cornerstone of communication and understanding within the Orapuh community. As an international, independent organization incorporated in the Republic of The Gambia as a charity, Orapuh is committed to promoting astute scholarship, professional proficiency, and open science in the field. This conceptual paper introduces and elucidates the Orapuh Vocabulary, providing clear definitions and pronunciation guides for key terms that encapsulate the ethos, mission, and activities of Orapuh. By presenting this comprehensive lexicon, the paper aims to facilitate communication, foster collaboration, and advance knowledge in oral and public health scholarship among professionals of Orapuh extraction</p>2024-03-20T14:54:12+00:00Copyright (c) 2024 V. E. Adamu, Ndidiamaka Ijeoma Eneojo