Scientists have discovered that ageing occurs in two rapid bursts, rather than gradually over time. This research, published on 14th August 2024 in the journal Nature Aging, reveals that these bursts take place at around 44 and 60 years of age. The study was led by Professor Michael Snyder from Stanford University and involved tracking 108 individuals aged between 25 and 75.
The participants provided blood, stool, and skin samples every few months over several years. The researchers found that significant changes in molecules and microbes often occurred around the mid-40s and early 60s. These changes may help explain why certain health issues, such as cardiovascular disease, tend to increase at these particular ages.
Initially, the scientists believed that the changes observed in the mid-40s might only apply to women due to menopause. However, the data revealed that similar changes also occurred in men, indicating that other factors are likely involved.
The first burst of changes includes molecules linked to heart disease and the body’s ability to process caffeine and alcohol. The second burst involves molecules related to the immune system, metabolism, and kidney function. This research might enable doctors to recommend lifestyle adjustments, such as increasing exercise, during these critical periods of ageing.